Bio‐Orthogonally Crosslinked, In Situ Forming Corneal Stromal Tissue Substitute
نویسندگان
چکیده
منابع مشابه
Rabbit study of an in situ forming hydrogel vitreous substitute.
PURPOSE An in situ forming hydrogel was evaluated as a potential vitreous substitute in rabbits. METHODS The hydrogel used a disulfide cross-linker that was then reduced to produce an injectable thiol-containing polymer solution. The disulfide cross-links reformed by air oxidation of the thiols and produced a stable hydrogel once inside the eye. The polymer was clear, autoclavable, and could ...
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PURPOSE The current and projected shortage of transplantable human donor corneas has prompted the development of long-term alternatives to human donor tissue for corneal replacement. The biosynthetic stromal substitutes (BSS) characterized herein represent a potentially safe alternative to donor organ transplantation for anterior corneal stromal diseases. The goal of this phase 1 safety study w...
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Per Fagerholm, Neil S Lagali, David J Carlsson, Kimberley Merrett and May Griffith, Corneal Regeneration Following Implantation of a Biomimetic Tissue-Engineered Substitute, 2009, CTS-CLINICAL AND TRANSLATIONAL SCIENCE, (2), 2, 162-164. which has been published in final form at: http://dx.doi.org/10.1111/j.1752-8062.2008.00083.x Copyright: Blackwell Publishing http://eu.wiley.com/WileyCDA/Brand...
متن کاملA simple, cross-linked collagen tissue substitute for corneal implantation.
PURPOSE To develop a simple corneal substitute from cross-linked collagen. METHODS Porcine type I collagen (10%; pH 5), was mixed with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The final homogenous solution was molded to corneal dimensions, cured, and then implanted into rabbits and minipigs by lamellar keratoplasty. The implants were followed for up ...
متن کاملIn-Situ Forming Biomimetic Hydrogels for Tissue Regeneration
Tissue loss or organ failure caused by injury or damage is one of the most serious and costly problems in human health care. Tissue engineering, proposed by Langer et al. in the early 1990’s (Langer & Vacanti, 1993), is an emerging strategy of regenerative biomedicine that holds promise for the restoration of defect tissues and organs. The concept of tissue engineering is defined as “the applic...
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ژورنال
عنوان ژورنال: Advanced Healthcare Materials
سال: 2018
ISSN: 2192-2640,2192-2659
DOI: 10.1002/adhm.201800560